Gell and Coombs Classification of Immune Reactions
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چکیده
Allergies represent TYPE I reactions according to the Gell and Coombs classification. Most are caused by IgE ANTIBODIES which are capable of binding to Fc-receptors for IgE on tissue MAST CELLS. Cross-linking of these membrane-bound IgE's by specific antigen results in mast cell DEGRANULATION; this process releases HISTAMINE and a variety of other effector molecules, which in turn results in the myriad symptoms of allergy. (rash, hay fever, asthma etc.) Passive cutaneous anaphylaxis (PCA) in the guinea pig and the Prausnitz-Küstner (P-K) skin reaction in humans provide models for understanding the underlying mechanism of allergic reactions. Management of allergies begins with allergen avoidance, and includes the use of a variety of drugs and allergen-specific DESENSITIZATION.
منابع مشابه
The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation.
Gell and Coombs classified hypersensitivity reactions into four 'types'. I suggest that the premise that these reactions represent 'hypersensitivity' manifestations is limiting and that they represent four major strategies that the body uses to combat infectious agents. I further propose that there is a fifth strategy that was not envisioned in the Gell and Coombs classification.
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